Effect and Mechanism of Liraglutide on Vasodilatation of Thoracic Aortic Ring in Experimental Rats / 中国循环杂志
Chinese Circulation Journal
;
(12): 50-53, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-462766
ABSTRACT
Objective:
To investigate the effect and mechanism of liraglutide on vasodilatation of thoracic aortic ring in experimental rats.Methods:
The thoracic aortic rings were isolated from 32 male SD rats and divided into 2 groups Without endothelium group and With intact endothelium group, n=16 in each group. The contractile force of vascular ring was detected and the effect of liraglutide (1×10-5 mol/L) on vasodilatation of norepinephrine (NE, 1×10-6 mol/L) pre-contracted ring was observed. The aortic ring in With intact endothelium group was further divided into 2 sub-groups①the aortic ring was pre-treated by the inhibitor of nitric oxide synthase (NOS) (L-NAME at 10-4 mol/L),② the aortic ring was pre-treated by non-specific ATP-sensitive-potassium (KATP) channel (Glibenclamide at 10-5 mol/L), n=8 in each group. The impacts of liraglutide on those 2 sub-groups were studied.Results:
Liraglutide had no effect on isolated aortic ring at basic condition. Liraglutide at (10-5 mol/L) had vasodilatation effect in both Without endothelium and With intact endothelium groups, the effect was stronger in With intact endothelium group and the maximum vasodilatation reached 17%, P reached 14%, P>0.05.Conclusion:
Liraglutide had obvious effect of vasodilatation on NE pre-contracted thoracic aortic ring in experimental rats, the mechanism might be related to NOS, while KATP channel could not block the vasodilatation effect of liraglutide.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Circulation Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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