Occurrence and risk factors of thyroid dysfunction in chronic hepatitis C patient received interferon treat-ment / 中国基层医药

ABSTRACT

Objective To investigate the antiviral treatment for patients with chronic hepatitis c(CHC)the influence of thyroid function and its related risk factors.Methods Used polyethylene glycol (peg) interferon (PegIFN α-2a)plus ribavirin (RBV)for the treatment of 122 cases of patients with CHC data were retrospectively analyzed.All of the patients before treatment thyroid function were normal.According to the thyroid function after treatment they were divided into normal thyroid function and abnormal thyroid function groups.Adopting the method of case -control study and Logistic regression we analyzed correlative risk factors of thyroid dysfunction.Results 122 CHC patients completed 48 weeks of treatment,and follow -up of 24 weeks,34 patients with thyroid dysfunction,rate of 27.9%. Logistic regression analysis showed that women,a positive thyroid autoantibodies,health care and smoking might be risk factor for thyroid dysfunction(OR =4.470,4.470,4.757 and 7.306,P <0.05 or P <0.01).Conclusion Inter-feron plus RBV during the treatment of CHC patients with a high incidence of thyroid dysfunction,including women,a positive thyroid autoantibodies,the health,and smoking could be a risk factor for thyroid dysfunction.