Study on protective effect and mechanism of caffeic acid phenethylester in rats with doxorubicin-induced myocardial injury / 中国生化药物杂志

ABSTRACT

Objective To study protective effect and mechanism of caffeic acid phenethyl ester ( CAPE ) in rats with doxorubicin-induced myocardial injury.Methods Sixty male SD rats were randomly divided into control group, model group and CAPE ( 12、24、48 mg/kg ) groups.The models of doxorubicin-induced myocardial injury were established by injection of 2.5 mg/kg doxorubicin every other day for 6 times.After the last injection, model group was given distilled water and CAPE ( 12、24、48 mg/kg ) groups were fed with CAPE, one time a day for 8 weeks.After consecutive 8 weeks, serum creatine kinase, lactate dehydrogenase and BNP were assessed , NO concentration, MDA,GSH,SOD,NOS,LPO and CAT contents in the heart were determined and histopathological changes were detected.Results serum creatine kinase、lactate dehydrogenase and BNP of CAPE 48 mg/kg group decreased significantly(P<0.05), while the activity of NO,NOS,GSH,CAT and SOD increased in the CAPE 48 mg/kg group significantly ( P<0.05 ) .Histopathology showed caffeic acid phenethyl ester could improve the doxorubicin-induced myocardium injury. Conclusion caffeic acid phenethylester has the protective effects in rats with doxorubicin-induced myocardial injury.Protective effect may be related to improve myocardial against oxidative stress damage.