Effects ofTiaozhi-Tongluo decoction combined with atorvastatin tablets on type 2 diabetes mellitus and lipid metabolism in patients with hyperlipidemia / 国际中医中药杂志

ABSTRACT

Objective To observe the effects ofTiaozhi-Tongluo decoction combined with atorvastatin tablets on type 2 diabetes mellitus and lipid metabolism in patients with hyperlipidemia.Methods All patients were recruited into a control group and an observation group. Patients in both groups were performed diet control, reasonable exercise, and routine oral sulfonylureas and biguanides to make glucose level in a normal range. The control group was treated with atorvastatin tablets, 20 mg/d. While the observation group was treated with atorvastatin tablets plusTiaozhi-Tongluo decoction. After both groups were treated for 6 months, the blood glucose and blood lipid level were detected for the evaluation of clinical curative effect.Results The total effective rates in the observation group and the control group were 87.5%(56/64)and 73.0%(46/63), respectively, the difference was statistically significant (χ2=4.213,P=0.040). The serum levels of total cholesterol (4.31 ± 1.11 mmol/Lvs.5.62 ± 1.34 mmol/L,t=6.004) and triglyceride (1.73 ± 0.53 mmol/Lvs. 2.57 ± 1.01 mmol/L,t=5.855) in the observation group were significant lower than those in the control group. The levels of fasting plasma glucose (6.31 ± 1.64 mmol/Lvs.7.21 ± 1.71 mmol/L,t=3.027) , 2-h postchallenge plasma glucose (8.81 ± 1.39 mmol/Lvs.9.69 ± 1.55 mmol/L,t=3.370), and glycosylated hemoglobin (6.79% ± 1.61%vs.7.96% ± 1.72%,t=3.958) in the observation group after treatment were significantly decreased than the control group (P<0.01).ConclusionTiaozhi-Tongluodecoction combined with atorvastatin can reduce serum total cholesterol and triacylglycerol, and it is superior to atorvastatin alone in reducing lipidemia in type 2 diabetes mellitus patients with hyperlipidemia.