Tissue-specific Changes of Clock DNA Promoter Methylation with Aging / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 514-518, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-464471
ABSTRACT
Objective To investigate the role of the clock gene promoter methylation in aging. Methods C57BL mice of 4-(young, n=9) and 20-(old, n=10) month-old were determined the promoter methylation level of clock genes (Per1/2, Bmal1/2, Cry1/2, Clock, Npas2) in the stomach, spleen, vascular, kidney and striatum with methylation-specific polymerase chain reaction (MSP). Results The incidence of promoter methylation of Cry1, Bmal2 and Npas2 in spleen increased in old mice (P<0.05), while the promoter methylation of Per1 in stom-ach decreased (P<0.05), and the promoter methylation of Bmal1 in vascular increased (P<0.05). Conclusion Promoter methylation of some clock genes is involved in process of aging in a tissue-specific way.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Ano de publicação:
2015
Tipo de documento:
Artigo
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