The concentrition change of serum 5-Hydroxy tryptamine and clinical symptoms improvement in primary premature ejaculation with the treatment of paroxitine / 国际检验医学杂志

ABSTRACT

Objective To investigate the relationship between concentration change of serum 5‐hydroxy tryptamine and clinical symptoms improvement in primary premature ejaculation with the treatment of paroxitine .Methods 81 cases of lifelong PE and an intra‐vaginal ejaculation latency time (IELT ) ≤60 s were included in this study .Subjects were divided into 2 groups according to the IELT ,group A (IELT≤30 s) and group B (30 sPatients of two groups were given paroxetine hydrochloride 20 mg/d for 8 weeks .Blood sample got from the candidates both in screening period and after 8 weeks of treatment .The plasma con‐centration of 5‐HT was measured by ELISA .All the data were statistically analyzed .Results The IELT and serum 5‐HT concent‐rition was significantly improved in both groups(P<0 .001);The change of mean IELT and serum 5‐HT concentrition of group A was significantly higher than group B(P<0 .001) .Conclusion The improvement of serum 5‐HT concentrition has the obvious uni‐formity with the clinical benifits in primary premature patients .