ReIationships between sodium channeI NaV 1.7 and pain / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 297-301, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-465562
ABSTRACT
Voltage-gated sodium channels (NaV1.1-NaV1.9) play important roles in the generation and maintenance of electrical excitability. NaV1.7 is preferentially expressed in peripheral somatic sensory neurons and sympathetic ganglion neurons. ln humans, gain-of-function mutations of SCN9A gene, which encodes NaV1.7, cause inherited neuropathic pain, whereas loss-of-function mutations result in a congenital indifference to pain without motor, cognitive and cardiac deficits. The effects of some analge-sics are associated, at least in part, with the NaV1.7 and selective NaV1.7 inhibitors have also been demonstrated to be analgesic in animal models. NaV1.7 has emerged as a potential target for the treat-ment of pain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2015
Tipo de documento:
Artigo
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