Reduced coenzyme Q10 in treatment of severe recurrent aphthous ulcer: a randomized, controlled trial / 中国医师进修杂志

ABSTRACT

Objective To observe the curative effect of reduced coenzyme Q10 in treatment of severe recurrent aphthous ulcer (RAU).Methods A total of 64 severe RAU patients were divided into experimental group (30 cases) and control group (34 cases) by random digits table method.The control group received conventional treatment,and the experimental group was treated with coenzyme Q10 on the basis of the control group.The clinical indicators were observed.Results Compared to patients on admission,the Hamilton Anxiety Scale (HAMA scale),disease uncertainty Scale (MUIS scale),visual analog pain scale (VAS index) after 2 weeks in hospital in the experimental group were decreased,and there were significant differences (P ＜ 0.05).Compared to the control group after 2 weeks in hospital,MUIS scale,VAS index were decreased in the experimental group,and there were significant differences (P ＜ 0.05).Compared to patients on admission,superoxide dismutase,CD4+,CD4+/CD5+ after 2 weeks in hospital in the experimental group were increased,malondialdehyde (MAD),fibrinogen were decreased,and there were significant differences (P ＜0.05).Compared to the control group after 2 weeks in hospital,MAD was decreased,CD4+,CD4+/CD5+ were increased in the experimental group,and there were significant differences (P ＜0.05).Compared to the control group,the ulcer duration in the experimental group was shorter [(13.75 ± 3.58) d vs.(16.89 ± 5.17) d],and there was significant difference (P ＜ 0.05).Compared to the control group,the efficiency was increased,the no efficiency was decreased,the total efficiency was increased,and there was significant difference (P ＜ 0.05).Conclusion Coenzyme Q10 is effective in treatment of severe RAU,worthy of promotion.