Induced pluripotent stem cells in bone tissue regeneration：how to achieve clinical application in orthopedic surgery as soon as possible? / 中国组织工程研究

ABSTRACT

BACKGROUND:Biomaterial combined with stem cels is revealing a bright future in bone tissue regeneration in orthopedic surgery. Induced pluripotent stem cels have better cel sources and characteristic, which have become a hotspot of stem cel field. OBJECTIVE:To review the research history, preparation method, cel characteristics of induced pluripotent stem cels and the research developments in orthopeadic surgery so far. METHODS:A computer-based search of CNKI and PubMed was performed for articles about induced pluripotent stem cels and their applications in the field of orthopeadic surgery published from 1999 to 2014. Typical and creative research achievements were enroled in result analysis. RESULTS AND CONCLUSION: Studies have shown that induced pluripotent stem cels have a potential application prospect in bone tissue regeneration, and they also show a satisfying biocompatibility with various scaffold materials, in which, the induced pluripotent stem cels can maintain a good osteogenetic potential. Detection methods and smal-molecule compounds have been discovered gradualy for cartilage regeneration. But how to effectively induce the chondrogenic differentiation of induced pluripotent stem cels and to realize the clinical applications need further research.