Scrambled biological motion perception in patients with early-middle Parkinson disease / 中国神经精神疾病杂志

ABSTRACT

Objective To explore scrambled biological motion perception in Parkinson’s disease (PD). Meth?ods Thirty individuals with idiopathic PD and matched health controls (HCs) underwent discrimination task.The severi?ty of disease was assessed based on the Hohen and Yahr scale. Results Compared with“PSE=0”,there was a significant negative PSE (the point of subjective equality) (-0.15 ± 0.18) for HCs ( t=4.56, P<0.001), suggesting a temporal dilation effect of the upright scrambled biological motion sequences in HCs. There was a significant difference in the PSE be?tween PD patients(t=3.72,P<0.001) and HCs. Patients in the PD group were then divided into two subgroups accord?ing to their status of disease. There were significant differences in PSE between early-stage PD patients (stage 1-2) (0.02±0.26) and HCs (P<0.01), and between mid-stage PD patients (stage 2.5-3) (0.06±0.12) and HCs (P<0.01). There was no significant difference in PSE between early-stage and mid-stage PD patients (P=0.61). Conclusion The present study suggests that there is a scrambled biological motion perception impairment in PD at the very early stage, which might be attributed to the dysfunction of the prefrontal lobe.