Tissue engineering technology for articular cartilage repair：how to construct a new compound pattern? / 中国组织工程研究

ABSTRACT

BACKGROUND:Articular cartilage has limited ability to repair itself, and the traditional means are difficult to repair articular cartilage defects, but articular cartilage tissue engineering provides new methods and approaches for large-area articular cartilage defects. OBJECTIVE:To review the current status, problems and prospects of tissue engineering technology in articular cartilage repair. METHODS:The retrieval of PubMed database was performed for articles published from 1982 to 2015, with the keywords of “articular cartilage, repair, tissue engineering” in English. Literatures related to tissue engineering repair of articular cartilage were included, but repetitive studies were excluded. Finaly 39 articles were reserved in result analysis. RESULTS AND CONCLUSION:Excelent seed cels have chondrogenic differentiation potential, and currently, the main seed cels for articular cartilage repair include mesenchymal stem cels, embryonic stem cels, adipose-derived stem cels and precartilaginous stem cels. Different growth factors, which can induce the in vivo growth of host parenchymal cels, improve seeded cel stability, and accelerate tissue regeneration, tend to be combined in clinical application. Composite scaffolds are also one of hot researches that can promote cell inoculation and spatial distribution as well as accelerate cell proliferation. To obtain the best effectiveness of articular cartilage repair, how to optimize seed cells, select and match scaffold materials to construct new types of composite patterns is an important direction in the future.