Changes in endothelial function in rats with subclinical hypothyroidism after levothyroxine treatment / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 360-362, 2015.
Article
em Zh
| WPRIM
| ID: wpr-468516
Biblioteca responsável:
WPRO
ABSTRACT
Established rat models with subclinical hypothyroidism (SCH) were divided into three groups:subclinical hypothyroid(SCH),SCH treated with levothyroxine (L-T4),and control group.The L-T4 group displayed lowered total cholesterol and endothelin levels compared with the SCH group[(1.29 ±0.05 vs 2.38 ±0.55) mmol/L,(98.54 ± 32.43 vs 160.62 ±37.25) nmol/L,both P<0.05].Nitric oxide levels,left ventricular systolic pressure,and blood flow in abdominal aorta were significantly higher in the L-T4 group than those in the SCH group.The results of this study indicate that L-T4 treatment may improve endothclial dysfunction and hemodynamic changes in rats with SCH.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Article