Comparison of fibrinolysis in patients undergoing nasal polypectomy under different methods of anesthesia / 中华麻醉学杂志

ABSTRACT

Objective To compare the fibrinolysis in the patients undergoing nasal polypectomy under different methods of anesthesia.Methods Forty ASA physical status Ⅰ or Ⅱ patients,scheduled for elective nasal polypectomy,were randomized into 2 groups (n =20 each) using a random number tablepropofol-based anesthesia group (group P) and sevoflurane-based anesthesia group (group S).Venous blood samples were taken before induction of anesthesia (T1),at 30 min after the beginning of operation (T2),and at the end of operation (T3) for determination of the levels of plasma cortisol,adrenocorticotropic hormone (ACTH),D-dimer (DD),tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1).Results Compared with the baseline value at T1,the plasma cortisol and ACTH levels were significantly decreased at T2,and no significant change was found at T3 in the two groups,and there was no significant difference between the two groups.The plasma DD,t-PA and PAI-1 levels were significantly higher at T2,3 than at T1.Compared with group P,the plasma DD and t-PA levels were significantly decreased at T2,3,while the plasma PAI-1 level was increased at T2.3 in group S.Conclusion Propofol-based anesthesia provides higher degree of enhancement in fibrinolysis than sevoflurane-based anesthesia and it is more suitable for the patients undergoing nasal polypectomy.