The combined analysis of susceptibility weighted imaging and proton spectroscopy sequence by high field magnetic resonance in the first-episode depression patients / 中华行为医学与脑科学杂志

ABSTRACT

Objective Combined with susceptibility weighted imaging (SWI) and proton magnetic resonance spectroscopy (1H-MRS) to study the hippocampus in the first-episode depression patients for exploring the causal relationship.Methods 20 first-episode depression patients and 20 healthy volunteers underwent SWI scanning and hippocampal 1H-MRS image,analysis and comparison the changes between the venous system and metabolism of two groups.Results Proton spectroscopy analysis showed that compared with the control group,bilateral hippocampal NAA/Cr(left hippocampusdepression group 0.95±0.77,control group 1.78±0.82; right hippocampusdepression group 1.12±0.74,control group 1.91 ± 0.80) and Cho/Cr (left hippocampusdepression group 1.08±0.83,control group 1.75±0.73 ; right hippocampusdepression group 0.91±0.68,control group 1.95 ±0.74) in the depression group was significantly lower,the difference was significant(NAA/Crt value in left and right were -3.14,-3.49,P＜0.05; Cho/Crt value in left and right were-3.25,-3.19,P＜0.05),however MI/Cr had no obvious changes (t value in left and right were 1.24,-1.27,P＞0.05).Magnetic sensitive scan showed depression group compared with the control group was significantly reduced in lateral vein diameter,length and branches (t value were 3.23,4.56,2.66,P＜0.05).Conclusion The SWI sequence and 1H-MRS imaging methods can become a new research idea about the central nucleus,and this idea may explain the causal relationship between the hippocampus in depression patients of vascular abnormalities and hippocampal neuronal metabolic abnormalities.