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Effect of protein kinase C inhibitor on the level of phosphralated extracellular regulated protein kinases in the spinal trigeminal nucleus of migraine model rats / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science ; (12): 1072-1074, 2014.
Artigo em Chinês | WPRIM | ID: wpr-470547
ABSTRACT
Objective To explore the effect of protein kinase C inhibitor on the level of phosphralated extracellular regulated protein kinases in the spinal trigeminal nucleus of migraine model rats.Methods Healthy adult male SD rats were randomly divided into four groupsnormal group (group C),sham operation group (group C),migraine model group(group M),and H-7group(H-7group),with 18 rats in each group.Dural blood flow and the extracellular discharge frequency in the spinal trigeminal nucleus was recorded.ERK1/2 phosphorylation was tested.Results (1) Dural blood flowcompared with group C((3.8± 1.0)%),the dural blood flow in M group ((78.0±4.2) %)increased obviously(P<0.01) ; compared with M group((78.0±4.2)%),the dural blood flow in H-7 group((-24.8±4.9) %) decreased obviously(P<0.01).(2) The percentage of extracellular discharge frequency changetwo hours after treatment,the percentage of extracellula discharge frequency change in group M ((325.9 ±47.3)%)was higher than that in group C((107.3±16.4)%).The percentage of discharge frequency change in group H-7((136.0±26.5)%) was lower than that in group M((325.9±47.3)%).There was no significant difference in the percentage of discharge frequency change between group H-7((136.0±26.5) %) and group C((107.3 ± 16.4)%).(2) ERK1/2 phosphorylationthe ERK1/2 phosphorylation in group M was higher than that in group C.The ERK1/2 phosphorylation in group H-7 was lower than than that in group C and group M.Conclusion ERK1/2 is a downstream PKC signal path and PKC may have indirect activation of ERK1/2.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Behavioral Medicine and Brain Science Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Behavioral Medicine and Brain Science Ano de publicação: 2014 Tipo de documento: Artigo