Association study between phosphodiesfierase-4A SNPs and bipolar disorder in the Han Chinese population / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore wbether there is an association between the single nucleotide polymorphisms (SNPs) of phosphodiestierase-4A (PDE4A) and bipolar disorder in Han population.Methods A casecontrol association study was done in this study,432 bipolar disorder patients(patients group),and 569 age and gender-matched controls(control group)were recruited.Real-time fluorescent quantitative polymerase chain reaction (PCR) was used to detect genotypes and alleles distributive frequency of rs1051738 and rs7256672 of 432 bipolar disorder patients and 569 normal people.Results The PDE4A rs1051738 genotypes and alleles frequency distribution between patients group(AA,AC,CC genotypes12％,8％,80％,A,C alleles16％,84％) and control group (AA,AC,CC genotypes2％,19％,79％,A,C alleles12％,88％) showed statistically significance (P＜ 0.01).The frequency of PDE4A rs7256672 genotypes and alleles distribution between patients group(GG,GT,TT genotypes18％,50％,32％,G,T alleles43％,57％) and control group (GG,GT,TT genotypes20％,48％,32％,G,T alleles45％,55％)showed no significant difference(P=0.620,P=0.446).Conclusion The PDE4A rs1051738 polymorphism may be responsible for an increase in susceptibility to bipolar disorder,indicating that it maybe a functional site with marked significance to bipolar disorder.