Research progress of TKTL1 in malignant neoplasms / 肿瘤研究与临床

ABSTRACT

Up to now,one transketolase (TKT) and two transketolase-like genes (TKTL1 and TKTL2) have been identified in the human genome.People have conducted a series of basic and clinical researches of TKTL1 in malignant neoplasms since Coy found TKTL1 has a high expression of protein and gene levels in the malignant tumors in 2005.Although the biochemical and functional mechanism have not been clarified clearly,a positive role of TKTL1 in promoting tumorigenesis and tumor progression has been proved.