Research front and hotspots of neuronal calcium sensor-1 / 中国组织工程研究

ABSTRACT

BACKGROUND:Research front and hotspots of neuronal calcium sensor-1 are always the focus for the researchers in this field. OBJECTIVE:To probe the research front and hotspots of neuronal calcium sensor-1 with the methods of quantitative analysis. METHODS:The methods of co-cited articles analysis and word frequency analysis were used in the article. The objects were 363 articles from Web of Science by US Institute for Scientific Information (ISI) about the neuronal calcium sensor-1 from 1982 to 2014. The network of co-cited articles and keywords was showed in visualization mapping by using CiteSpace III in which the burst nodes represented the high impact hot papers and the most frequently used keywords, and revealed the research frontier and the hot spots of neuronal calcium sensor-1. RESULTS AND CONCLUSION:The physiological functions of neuronal calcium sensor-1 are the research frontier and the hot spots. The transformational point in time spot of the hotspots is during 1994 to 1996, 2000, 2008, 2012;and the different research focus showed in each stagethe structure and characterization of the protein during 1992-2000 and the protein function and the role during 2004-2012 are the research hotspots, while during 2008-2014 the hotspots place extra emphasis on the higher function (e.g. memory) and several diseases(such as schizophrenia, cancer, autism, depression, senile dementia, neuron damage, etc). The determination of the research frontier domains and hot spots of neuronal calcium sensor-1 wil indicate the goal and direction for the further studies.