Expression and Clinical Significance of Fascin Protein and VEGF in Bladder Transitional Cell Carcinoma / 天津医药

ABSTRACT

Objective:To investigate the relationship between the expression of Fascin protein and vascular endothelial growth factor(VEGF)and the biological behavior of bladder transitional cell carcinoma(BTCC).Methods:The expressions of Fascin and VEGF were examined by SABC(StreptAvidin-Biotin Complex)immunohistochemistry in 56 paraffin-embedded tissue specimens and 10 control samples of normal bladder tissues.Results:The positive expression rates of Fascin and VEGF were 0 in normal bladder tissue.The positive expression rates of Fascin and VEGF were 73.21% and 60.71% in BTCC(P ＜ 0.01).The higher expressions of Fascin and VEGF were related to the tumor grade,clinical stage and recurrence(P ＜ 0.01).The expression of Fascin was closely correlated with that of VEGF in BTCC(r=0.476 9,P＜ 0.01).Conclusion:The expression of Fascin may be one of parameters for understanding the biological behavior of BTCC.Fascin protein and VEGF may enhance the influence of the development of BTCC together,which may also provide theoretical foundation of chemopreventive stategy for bladder cancer in the future.