Analysis of Expression of Multidrug Resistance Gene and Multidrug Resistance-Associated Protein Gene in Patients with Non-small-cell Lung Cancer / 天津医药
Tianjin Medical Journal
;
(12): 738-739, 2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-472476
ABSTRACT
Objective:
To investigate the expression of multidrug resistance (MDR1) gene and multidrug resistance-associated pro-tein (MRP) gene in patients with non-small-cell lung cancer (NSCLC) and its relation to histopathological type.Methods:
The MDRi and MRP genes were determined by reverse transcription-polymerase chain reaction (RT-PCR) in 48 NSCLCspecimens.Results:
The positive rates of the MDR1 and MRP gene expression were 62.5% and 66.7% respectively in the48 patients. Twenty-one of the 48 NSCLCs (43.8%) expressed both MDR1 and MRP genes. The positive rates of the MRPgene expression in squamous cell carcinoma was significantly higher than those in adenocarcinoma (P<0.01), and therewas no significant difference in MDR1 gene expression between the two groups (P>0.05).Conclusion:
The MDR1 andMRP gene expressions were both or respectively in the NSCLCs. The incidence of the MRP gene expression in squamous cellcarcinoma was higher than that in adenocarcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Tianjin Medical Journal
Ano de publicação:
2000
Tipo de documento:
Artigo
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