Spectrophotometric method for the determination of ketoconazole based on amplification reactions / 药物分析学报
Journal of Pharmaceutical Analysis
;
(6): 43-47, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-472630
ABSTRACT
This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions.Ketoconazole was oxidized with periodate,resulting in formation of KC2+ and iodate ions.After masking the excess periodate with molybdate,the iodate was treated with iodide to release iodine.The liberated iodine was transformed to ICl2ˉspecies and extracted as ion-pair with rhodamine 6G into toluene for spectrophotometric measurement at 535nm.A linear calibration graph was obtained between 0.2136μg/mL and 1.7088 μg/mL of Ketoconazole with a molar absorptivity of 5 × 105 mol.L-1 cmˉ 1.The procedure was successfully applied for the determination of ketoconazole in tablet formulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Pharmaceutical Analysis
Ano de publicação:
2012
Tipo de documento:
Artigo
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