Impact on postoperative outcomes after red blood transfusion in coronary artery bypass graft surgey: a meta-analysis of current evidence / 中华胸心血管外科杂志

ABSTRACT

Objective To systemically assess impact on postoperative outcomes after red blood cell transfusion(RBCT) in coronary artery bypass graft surgey.Methods A meta-analysis was performed on the comparison and synthesis of findings from included studies published from January 1980 to January 2014.Pooled odds ratio(OR) and 95 ％ confidence interval(CI) were calculated using RevManS.3 software.Sensitivity analysis was conducted and possible publication bias was tested as well.Results Seven retrospective studies including 71 228 patients(33 872 RBCT cases,37 356 control cases) were eligible for inclusion.The pooled analysis revealed difference in the 30-day mortality OR =1.85 (95％ CI1.35-2.54),1-year mortality OR =2.02 (95 ％ CI1.44-2.84),shock OR =2.92 (95 ％ CI1.96-4.35),renal dysfunction OR =7.67 (95 ％ CI1.44-40.94),mediastinitis OR =2.26 (95 ％ CI1.72-2.97),and myocardial infarction OR =3.53 (95 ％ CI2.89-4.29).Conclusion Perioperative RBCT can incresase the risk of postoperative mortality and complications in coronary artery bypass graft surgey.High-quality randomized case cohort studies are still needed for the further proof of the risk.