Research process of apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like in tumors / 肿瘤研究与临床

ABSTRACT

Apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like (APOBECs) is a group of cytidine deaminases,which represents somewhat unusual protein family that can insert mutations in DNA and RNA as a result of their ability to deaminate cytidine to uridine.APOBECs seem to have diverse roles,such as lipid transport,antigen-driven antibody diversification and acting an innate defense system against retroviruses.In recent years,other functions of APOBECs were identified.Notably,APOBECs can cause host genome mutations and are upregulated in multiple cancers,such as breast,cervix,lung,liver cancers and so on.The researches on APOBEC and its relations with in tumors were reviewed.