Clinical Significance of CK19, CD56 and p53 in differential diagnosis of papillary thyroid microcarcinoma and thyroid papillary hyperplasia / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 171-174, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-473110
ABSTRACT
Objective To investigate the expression and diagnostic significance of CK19,CD56 and p53 protein in papillary thyroid microcarcinoma and thyroid papillary hyperplasia.Methods The expressions of CK19、CD56 and p53 protein were detected in 52 cases of papillary thyroid microcarcinoma and 31 of thyroid papillary hyperplasia by iImmunohistochemical methods.Results The positive rate of CK19 expression was 100 % (52/52) of papillary thyroid microcarcinoma and 29.0 % (9/31) in 31 of thyroid papillary hyperplasia.There was significant difference between two groups (P < 0.001).CK56 in 2 cases (3.8 %) of papillary thyroid microcarcinoma appeared mild positive expression,and in 20 cases (66.7 %) of thyroid papillary hyperplasia positive expression (P < 0.001).The positive expression rates of p53 were 69.2 %(36/52) in papillary thyroid microcarcinoma and 6.5 % (2/31) in thyroid papillary hyperplasia (P < 0.001).Conclusion CK19,CD56 and p53 may be important value on differential diagnosis of papillary thyroid microcarcinoma from thyroid papillary hyperplasia,and they are the indispensable markers of differential diagnosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Cancer Research and Clinic
Ano de publicação:
2015
Tipo de documento:
Artigo
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