Effect of Type-A Character on Endothelial Function in the Elderly / 天津医药
Tianjin Medical Journal
;
(12): 556-558, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-473216
ABSTRACT
Objective:
To investigate the effect of type-A character on endothelial function in the elderly.Methods:
According to type-A character scale of Zhang Baiyuan, type-A character group and non-type-A character group were screened from the normal elderly, 60 eases for each respectively. Flow-mediated diastolic function of brachial artery was examined by high-frequency eehocardiography, which was reflected by diastolic inner diameter changing rate (D %). Other parameters included height, weight, body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose (FPG), triglyceride (TG), total cholesterol(TC), low-density lipoprotein-cholesterol (LDL-C), nitric oxide (NO), endothelin (ET)and angiotensin Ⅱ (AngⅡ). All of the parameters and the scores of type-A character were compared and analyzed between the two groups.ResultS:
(1) The levels of SBP and DBP were significantly higher in type A character group than those of non-type A character group (P<0.05). There were no significant differences in values of FPG, TC, TG and LDL-C between two groups (P>0.05). (2) The values of D% and NO were significantly lower in type A character group than those of non-type-A character group (P<0.05 ). The values of Ang Ⅱand ET were significantly higher in type-A character group than those of non-type-A group (P<0.05 ). (3)Pearson correlation analysis indicated that the scores of type-A character were positively correlated with Ang Ⅱ, ET, SBP and DBP (P<0.05, P<0.01), but negatively correlated with D% and NO (P<0.05). Multiple linear stepwise regression analysis showed that only Ang Ⅱwas an independent risk factor for type-A character.Conclusion:
h was showed that the increased Ang Ⅱinduced by abnormal activation of reunin-angiotensin-aldosteerone system (RAAS)may be the main mechanism of endothelial dysfunction in the eldedy with type-A character.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Fatores de risco
Idioma:
Chinês
Revista:
Tianjin Medical Journal
Ano de publicação:
2009
Tipo de documento:
Artigo
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