Relationship among thyroid function,FT3 level and coronary artery disease in patients with coronary heart disease / 心血管康复医学杂志

ABSTRACT

Objective:To explore the relationship among thyroid function ,free thyroxine (FT3) level and coronary artery disease in patients with coronary heart disease (CHD) .Methods :A total of 238 CHD patients ,who hospital-ized in our hospital from 2012 to 2014 and were proved by coronary angiography (CAG) ,were selected .Their thy-roid function was analyzed .After patients with hyperthyroidism ,hypothyroidism ,subclinical hyperthyroidism and subclinical hypothyroidism were excluded ,the remaining 217 patients were divided into normal FT3 group (n=192) and low FT3 group (n=25) according to FT3 level . General clinical condition and CAG results were compared be-tween two groups . Results:(1 ) Among the 238 CHD patients , there were two cases with hyperthyroidism (0.84% ) ,11 cases with hypothyroidism (4.62% ) ,three cases with subclinical hyperthyroidism (1.26% ) ,five ca-ses with subclinical hypothyroidism (2.10% ) and 25 cases with low T3 syndrome (10.50% );(2) Compared with normal FT3 group ,there were significant rise in levels of total cholesterol [TC ,(4.14 ± 1.59) mmol/L vs .(7.33 ± 1.72) mmol/L] ,apoprotein E [ApoE ,(3.91 ± 0.98) mmol/L vs .(4.55 ± 1.52) mmol/L] ,creatinine [Cr ,(97.99 ± 30.85)μmol/L vs .(116.64 ± 43.20) μmol/L] and N terminal pro brain natriuretic peptide [NT-proBNP ,140 (62~462) pg/ml vs .739 (304~4922) pg/ml] in low T3 group , P<0.01 all;(3) In CHD patients ,percentage of triple-vessel coronary disease in low FT3 group was significantly higher than that of normal FT3 group (76.0% vs . 40.1% , P<0.01) .Conclusion:Low free thyroxine syndrome is a most frequent thyroid dysfunction in patients with coronary heart disease ,and patients with low free thyroxine are more likely to involve multi-vessel disease .