Clinical and Pathological Features of Canceration of Epidermoid Cyst / 天津医药

ABSTRACT

Objective To study and research the clinical pathologic features, immunohistochemistry and prognosis of epidermoid cyst with cancerous changes. Methods Six cases of epidermoid cyst with cancerous changes were studied of their clinical pathologic features and immunohistochemistic expression and their prognosis was evaluated by follow-up vis-its. Results Clinical features All six cases showed local enclosed mass and underwent extensive resection. No recur-rence nor metastasis were shown in one year follow up. Pathological examination show irregular cystic mass with bean curd like fillings in it. Microscopic examination showed those cysts were lined with squamous epithelium which indicate invasive growth. Pathological diagnosis Epidermoid cyst canceration to squamous cell carcinoma. Immuno-phenotype CK 5/6 and P63 were positive in all six squamous cell cancer cases. Conclusion Epidermoid cyst with cancerous changes are quite rare. Diagnosis of the tumor largely relies on histopathology and immunohistochemical markers also assist diagnosis. Local appropriate expanded resection is preferred. Its malignant degree is low and prognosis is good.