The relationship between transcription factor NF-E2-related factor 2 and liver diseases / 中华实用儿科临床杂志

ABSTRACT

The liver is the most exuberant organs of human metabolism,susceptible to oxidative stress injury.More and more studies in recent years show that various types of liver diseases such as hepatitis,liver fibrosis,liver cirrhosis,liver cancer and so on are closely related with oxidative stress injury.The transcription factor NF-E2-related factor 2 (Nrf2) is an important transcription factor regulating oxidative stress reaction.It combines with the antioxidant response element antioxidant response elements (ARE),then activates target gene transcription,and increases the resistance of cell to oxidative stress.Kelch-like ECH-associated protein 1-Nrf2-ARE pathway plays an important role in the pathogenesis of liver diseases.