Association between maternal MTHFR C677T polymorphism and neural tube defects in offsprings:a Meta-analysis / 天津医药
Tianjin Medical Journal
;
(12): 552-558, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-473847
ABSTRACT
Objective To explore the association between maternal methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and neural tube defects (NTDs). Methods CBM, VIP, CNKI, Wanfang, PubMed and Web of Science databases from set up to March, 2014 were electronically searched to identify case-control studies on the relationship between maternal MTHFR C677T polymorphism and NTDs. The data were quantitatively analyzed by RevMan 5.0 software. Results A total of 25 studies were selected including 2 282 cases and 3 420 controls. Overall, the pooled OR (with 95%CI) under co-dominant model and allele contrast were 2.28(1.60-3.24), 1.25(1.02-1.53) and 1.42(1.21-1.67). Subgroup analysis showed significant association between maternal MTHFR C677T polymorphism and NTDs susceptibility in Asian populations. Conclusion The present meta-analysis suggests that MTHFR C677T polymorphism is significantly associated with maternal risk for NTDs, especially in Asian populations.
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Tianjin Medical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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