Dendritic Cell Functions in Allergen Recognition and Response / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 87-97, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-47423
ABSTRACT
Dendritic cells (DCs) are crucial in the defense against pathogens and allergen. The ability of allergens to cause allergic inflammation is contingent upon the presence of microenvironment that either privileges Th2 responses or prohibits these reactions. As a simplification, this review tried to prove a causal relationship between a allergic disease and dendritic cell by satisfying the modified Koch's postulates. DCs express C-type lectin receptors (CLRs) and Toll like receptors (TLRs). DCs take up almost all allergen through CLRs. Uptake of allergen by CLRs leads to the production of anti-inflammatory reactions. Although both TLRs and CLRs have distinct functions, the balance between both receptors is instrumental for the immunological outcome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Dendríticas
/
Alérgenos
/
Lectinas Tipo C
/
Receptores Toll-Like
/
Inflamação
/
Células Apresentadoras de Antígenos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Ano de publicação:
2005
Tipo de documento:
Artigo
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