Determination of Clindamycin Phosphate in Compound Sodium Phenytoin Gels by HPLC / 中国药师
China Pharmacist
;
(12): 690-691, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-474393
ABSTRACT
Objective:
To establish an HPLC method for the determination of clindamycin phosphate in compound phenytoin sodi-um ge1s.Methods:
The HPLC analysis was carried out on a ZORBAX SB-C18 column(250 × 46 mm,5 μm)with 0. 1 mol·L-1 KH2PO4 solution(adjusting pH to 2. 5 with H3PO4 solution)-acetonitrile(7525)as the mobile phase at the flow rate of 0. 8 ml· min-1 . The detection wavelength was 210 nm,the column temperature was 25℃ and the injection volume was 10μl.Results:
The lin-ear range of clindamycin phosphate was 3. 00-18. 00 μg(r=0. 999 5). The average recovery was 101. 11%(RSD=0. 34%,n=6).Conclusion:
The method is simple,sensitive and reproducible,and can be used in the determination of clindamycin phosphate in com-pound phenytoin sodium gels.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2015
Tipo de documento:
Artigo
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