Recent Research in Role of CD4+CD25+Regulatory T Cell in Pathogenesis of Immune Thrombocytopenia / 天津医药
Tianjin Medical Journal
;
(12): 390-392, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-474792
ABSTRACT
Immune thrombocytopenia (ITP), the most common hemorrhagic disease, is an organ-specific autoimmune disease characterized by decreased platelets count due to auto-antibodies mediating platelets destruction and insufficient platelets production. The etiology of ITP is still not completely known. Regulatory T cells, also called Tregs, are character-ized by CD4+CD25+, and positive of transcription factor forkhead box P3. They belong to a subpopulation of T cells special-ized for immune regulation and play an important role in maintaining the immune balance. Decreased production and defect-ed function of CD4+CD25+Treg was found not only in the ITP animal model but also in the ITP patients. It indicates that the Treg was involved in the pathology of ITP. This review focus on the characteristic and function of Tregs and their relationship with pathogenesis of ITP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Idioma:
Chinês
Revista:
Tianjin Medical Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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