Research progress of Bruton tyrosine kinase in B cell malignances / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 378-380, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-475034
ABSTRACT
Bruton tyrosine kinase (Btk) is a member of the non-receptor protein tyrosine kinases of Tec family.It plays an important role in growth,proliferation,differentiation and signal transduction of B lymphocyte.After activation of B-cell receptor (BCR) by diverse stimuli,Btk is activated through tyrosine phosphorylation.Activated Btk can stimulate several downstream signaling proteins.Btk and BCR signaling pathways play important roles in initiation and maintenance of B cell malignancies.This review focuses on the recent findings in association of Btk and B cell malignancies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2014
Tipo de documento:
Artigo
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