Adverse reactions of fludarabine in the treatment of chronic lymphoproliferative disorders / 白血病·淋巴瘤

ABSTRACT

Fludarabine (Flu) is a synthetic purine analog,which has been widely used in the treatment of B-cell chronic lymphoproliferative disorders (B-CLPD) such as chronic lymphocytic leukemia (CLL),nonHodgkin lymphoma (NHL) as an anti-metabolic cytotoxic chemotherapeutic drug and achieved good effect.Main adverse reactions in clinical application of Flu are dose-dependent bone marrow suppression and secondary infection.Non-hematologic adverse reactions are so rare and mild that most patients can tolerate.