Retrospective study for the combined effects of Ibuprofen and Cimetidine on the inhibition of penile erection postoperative penis / 中国基层医药

ABSTRACT

Objective Explore the combined effects of Ibuprofen and Cimetidine on the inhibition of penile erection postoperative penis after circumcision.Methods Reviewed 557 circumcision cases,patients were divided into 3 groups according to the drugsDiethylstilbestrol group(D group),Ketoconazole group(K group)and the group combined Ibuprofen with Cimetidine(F&C group).D group(n =156)were treated by Diethylstilbestrol for 5 days from the day of operation.K group(n =188)were treated by Ketoconazole for 5 days from the day of operation.F&C group (n =213) were treated by Ibuprofen and Cimetidine for 5 days from the day of operation.6 postoperative indices were compared for evaluating the effects of different drugs on the inhibition of penile erection postoperative penis,including the incidences of secondary hemorrhage,drug adverse reaction,morning erection,the pain frequency,pain degree and holding time of duration of nocturnal penile erection.Results The 4 indices of D group were 6.4％,96.8％,(4.8 ± 2.18) times,(13.6 ± 6.39) minutes,including the incidences rate of secondary hemorrhage and morning erection,the pain frequency and holding time of duration of nocturnal penile erection.These 4 indices of K group and F&C group were 1.6％,91.0％,(4.2 ± 2.21) times,(10.5 ± 5.35) minutes and 1.4％,89.7％,(4.1 ± 2.20) times,(10.4 ± 5.67) minutes.These 4 indices of F&C group were significant less or lower than D group(P ＜ 0.05),but were no significant differences than K group(P ＞ 0.05).It is listed in lighting the penile pain degree,D group,K group,F&C group(P ＜0.05).While the difference of adverse drug reaction rates had no statistically significant among 3 groups (P ＞ 0.05).Conclusion Though the adverse drug reaction rate of the medication combined Ibuprofen with Cimetidine is similar to Ketoconazole and Diethylstilbestrol, most of adverse drug reactions of the former in routine dose were stomach discomforts that could be lower risk than drug hepatitis,and there is no altercation or dispute on transnormal drug dose.The combined effects of Ibuprofen and Cimetidine in routine dose is very similar to Ketoconazole on the inhibition of penile erection postoperative penis,and is signifcantly better than Diethylstilbestrol.The medication combined Ibuprofen with Cimetidine is the best efficacity in the relief of pain among 3 kinds of medication,which is worth popularizing and applying.