Research progress of double-hit lymphoma / 白血病·淋巴瘤

ABSTRACT

Double-hit lymphoma is usually defined to be large B-cell lymphoma with MYC gene rearrangement combined with bcl-2 and/or bcl-6 gene rearrangement.It is highly aggressive with poorer prognosis after R-CHOP treatment and so far,its optimal therapy has not been developed.This article reviewed new advances in diagnosis,biology,prognostic factors and treatment of DHL in order to deepen insights,optimize therapy and improve prognosis of DHL.