Relationship between the Level of HBV DNA,ALT and the Titers of HBeAg with Effects of Entecavir in Chronic Hepatitis B Patients / 现代检验医学杂志

ABSTRACT

Objective To evaluate the efficiency of entecavir in chronic hepatitis B (CHB)patients.Meathods 60 cases of pa-tients treated with entecavir 0.5 mg/d.Observed the negative rate of HBV DNA and ALT after 3,6 and 12 months.Used immuno chemiluminescence to observe the HBeAg titer after medication.Results The negative rate of ALT and HBeAg, HBeAg conversion rate were 91.7%,86.7% and 16.7%,respectively.The titer of HBeAg was low at baseline,the patients would had higher HBeAg seroconversion,there were significant differences with other groups.The titer of HBeAg decreased≥90% patients was significantly higher in patients with < 90% on the 3 months.Conclusion The HBeAg titer could be predicted ETV for treatment of HBeAg positive CHB patients.