Effect of vitamin, folic acid combined with Ginkgo biloba extract on cognitive function in elderly patients with stroke / 中国生化药物杂志

ABSTRACT

Objective To analysis the effect of vitamin, folic acid combined with Ginkgo biloba extract on cognitive function in elderly patients with stroke.Methods 56 patients who were diagnosed with acute cerebral infarction were collected.All patients were randomly divided into experimental group and control group, 28 cases in each group.Control group was given conventional treatment for improving circulation, nutrition brain cells, anti platelet aggregation, experimental group was given vitamin B6 tablets(20 mg,one time per day), folic acid tablets(20 mg, one time per day) and Ginkgo Biloba Extract Tablets(80mg, two times per day) on the basis of conventional treatment.After treatment, the levels of plasma Hcy, serum BDNF, UCP2 level and cognitive function were detected in all patients.ResuIts After treatment, compared with control group, the plasma Hcy level was significantly lower in experimental group(P<0.05).The serum BDNF level in experimental group was significantly higher (P<0.05) .The serum UCP2 level in experimental group was significantly higher (P<0.05) .The MMSE and MoCA scores of the patients in the experimental group were significantly higher (P<0.05).ConcIusions Vitamin, folic acid combined with Ginkgo biloba extract can reduce the level of plasma Hcy in elderly patients with stroke, improve serum BDNF, UCP2 levels, improve the cognitive function.