Protective effects of sodium ferulate and oxymatrine on rats cerebral ischemia-reperfusion injury by reducing oxidative stress / 国际中医中药杂志

ABSTRACT

Objective To observe the protective effects of Sodium Ferulate (SF) combined with Oxymatrine (OMT) on rats cerebral ischemia-reperfusion injury (CIRI) and its mechanisms.Methods Rats were divided into a sham-operation, a model, a edaravone, a SF, a OMT and a low, a middle, a high dose of combination groups by random number table, with each group contained 12 rats. Edaravone (3 mg/kg), SF (25 mg/kg), OMT (50 mg/kg) and combination (SF 12.5 mg/kg + OMT 25 mg/kg; SF 25 mg/kg + OMT 50 mg/kg; SF 50 mg/kg + OMT 100 mg/kg) were injected intravenously to the rats. Normal saline were injected to rats of the sham-operation and the model groups. One injection was operated for continuous 5 days. At 30 minutes after last administration, CIRI was made on rats except for sham-operation. At 24 hours after reperfusion, rats were sacrificed. Infarcts volumes, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured.Results Infarcts volumes (F=73.183,P<0.01) and MDA contents (F=17.104,P<0.01) were significantly reduced and SOD vitalities (F=11.417,P<0.01) was increased in the SF, OMT and the combination groups. Effects of the combination groups were significantly better than the SF or the OMT groups (P<0.05). Conclusion Combination of SF and OMT had good effects to treat CIRI. The mechanisms were connected with anti-oxidative damages.