Difference in the rate of rectal complications following prostate brachytherapy based on the prostate-rectum distance and the prostate longitudinal length among early prostate cancer patients
Korean Journal of Urology
;
: 637-643, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-47849
ABSTRACT
PURPOSE:
To investigate the difference in rectal complications rate following prostate low dose rate (LDR) brachytherapy based on prostate-rectum distance and prostate longitudinal length among early prostate cancer patients. MATERIALS ANDMETHODS:
From March 2008 to February 2013, 245 prostate cancer patients with a Gleason score or =6 months were evaluated for radiation proctitis. Magnetic resonance imaging (MRI) was performed for a prebrachytherapy evaluation, and prostate-rectum distance and prostate longitudinal length were measured. The radiation proctitis was confirmed and graded via colonoscopy based on the radiation therapy oncology group (RTOG) toxicity criteria.RESULTS:
Twenty-three patients received a colonoscopy for proctitis evaluation, and 12 were identified as grade 1 on the RTOG scale. Nine patients were diagnosed as grade 2 and 2 patients were grade 3. No patient developed grade 4 proctitis. The rectal-complication group had a mean prostate-rectum distance of 2.51+/-0.16 mm, while non-rectal-complication control group had 3.32+/-0.31 mm. The grade 1 proctitis patients had a mean prostate-rectum distance of 2.80+/-0.15 mm, which was significantly longer than 2.12+/-0.31 mm of grades 2 and 3 patient groups (p=0.045). All 11 patients of grades 2 and 3 had a prostate longitudinal length of 35.22+/-2.50 mm, which was longer than group 1, but the difference was not statistically significant (p=0.214).CONCLUSIONS:
As the prostate-rectum distance increased, fewer postimplantation rectal symptoms were observed. Patients with a shorter prostate-rectum distance in MRI should receive modified implantation techniques or radical prostatectomy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho do Órgão
/
Proctite
/
Próstata
/
Neoplasias da Próstata
/
Lesões por Radiação
/
Índice de Gravidade de Doença
/
Braquiterapia
/
Imageamento por Ressonância Magnética
/
Carcinoma
/
Colonoscopia
Tipo de estudo:
Estudo prognóstico
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Urology
Ano de publicação:
2015
Tipo de documento:
Artigo
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