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Difference in the rate of rectal complications following prostate brachytherapy based on the prostate-rectum distance and the prostate longitudinal length among early prostate cancer patients
Korean Journal of Urology ; : 637-643, 2015.
Artigo em Inglês | WPRIM | ID: wpr-47849
ABSTRACT

PURPOSE:

To investigate the difference in rectal complications rate following prostate low dose rate (LDR) brachytherapy based on prostate-rectum distance and prostate longitudinal length among early prostate cancer patients. MATERIALS AND

METHODS:

From March 2008 to February 2013, 245 prostate cancer patients with a Gleason score or =6 months were evaluated for radiation proctitis. Magnetic resonance imaging (MRI) was performed for a prebrachytherapy evaluation, and prostate-rectum distance and prostate longitudinal length were measured. The radiation proctitis was confirmed and graded via colonoscopy based on the radiation therapy oncology group (RTOG) toxicity criteria.

RESULTS:

Twenty-three patients received a colonoscopy for proctitis evaluation, and 12 were identified as grade 1 on the RTOG scale. Nine patients were diagnosed as grade 2 and 2 patients were grade 3. No patient developed grade 4 proctitis. The rectal-complication group had a mean prostate-rectum distance of 2.51+/-0.16 mm, while non-rectal-complication control group had 3.32+/-0.31 mm. The grade 1 proctitis patients had a mean prostate-rectum distance of 2.80+/-0.15 mm, which was significantly longer than 2.12+/-0.31 mm of grades 2 and 3 patient groups (p=0.045). All 11 patients of grades 2 and 3 had a prostate longitudinal length of 35.22+/-2.50 mm, which was longer than group 1, but the difference was not statistically significant (p=0.214).

CONCLUSIONS:

As the prostate-rectum distance increased, fewer postimplantation rectal symptoms were observed. Patients with a shorter prostate-rectum distance in MRI should receive modified implantation techniques or radical prostatectomy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho do Órgão / Proctite / Próstata / Neoplasias da Próstata / Lesões por Radiação / Índice de Gravidade de Doença / Braquiterapia / Imageamento por Ressonância Magnética / Carcinoma / Colonoscopia Tipo de estudo: Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho do Órgão / Proctite / Próstata / Neoplasias da Próstata / Lesões por Radiação / Índice de Gravidade de Doença / Braquiterapia / Imageamento por Ressonância Magnética / Carcinoma / Colonoscopia Tipo de estudo: Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2015 Tipo de documento: Artigo