Observation on Efficacy of Compound Sophorae Flavescentis Radix Injection Combined with Oxycodone Hydrochloride in Treating Lung Cancer Pain / 中国中医药信息杂志

ABSTRACT

Objective To observe the near-term efficacy of Compound Sophorae Flavescentis Radix Injection combined with oxycodone hydrochloride in treating lung cancer pain.Methods Sixty patients with advanced lung cancer were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was treated by the best symptomatic and supportive treatment combined with oxycodone hydrochloride, while the treatment group was treated by Compound Sophorae Flavescentis Radix Injection 20 mL which was added into 250 mL normal saline solution for intravenous drip additionally, once a day for 14 days. KPS score before and after treatment, analgesic effect, and adverse action of the two groups were observed.Results After treatment, the pain in patients of treatment group was significantly improved (P0.05). KPS in patients of treatment group was significantly improved compared with that of before treatment and the comrol group, with statistical significance (P>0.05). There was no statistical significance in KPS score between before and after treatment of the control group (P>0.05).Conclusion Compound Sophorae Flavescentis Radix Injection combine with oxycodone hydrochloride can significantly relieve patients’ pain and improve their life quality, with no obvious adverse reactions.