Changes and clinical significance of serum interleukin 17,interleukin 18 and interleukin 18 binding protein in patients with aplastic anemia / 中国基层医药

ABSTRACT

Objective To explore the clinical significance of changes of serum.interleukin 17(IL -17), interleukin 18(IL -18)and interleukin 18 binding protein(IL -18BP)in patients with AA.Methods Serum IL -17,IL -18 and IL -18BP levels were measured by ELISA in 50 patients with AA and 52 health control.Results The levels of serum IL -17,IL -18 and IL -18BP in the AA group were (216.41 ±22.24)μg/L,(402.37 ± 59.76)ng/L and (8.79 ±2.61 )μg/L respectively,which were higher than those in the healthy control group of (90.36 ±9.78)μg/L,(136.48 ±20.25)ng/L and (2.01 ±0.68)μg/L(t =37.41,30.46,18.13,all P <0.01). And the levels of serum IL -17,IL -18 and IL -18BP in AAA group were (267.76 ±30.17)μg/L,(479.41 ± 68.76)ng/Land (11.72 ±3.29)μg/L,which were higher than those in the CAA group of (156.48 ±18.36)μg/L, (312.47 ±40.61)ng/L and (5.36 ±1.45)μg/L (t =15.73,10.43,8.92,all P <0.01).The serum level of IL -17 was positive correlation with the levels of IL -18 and IL -18BP in patients with AA (r =0.527,r =0.489,all P <0.05),the serum level of IL -18 was also positive correlation with the level of IL -18BP(r =0.731,P <0.01). Conclusion IL -17,IL -18 and IL -18BP may participate in the pathogenesis of AA,and there is a certain correla-tion,which may influence the process of AA.