The value of combined detection of PTH,β2-MG and hs-CRP in differentiating diagnosis of acute and chronic renal failure / 天津医药

ABSTRACT

Objective To explore the value of combined detection of parathyroid hormone(PTH),β2-microglobulin(β2-MG)and high sensitivity C-reactive protein(hs-CRP)in differentiating diagnosis of acute and chronic renal failure. Meth?ods Patients diagnosed with renal failure was divided into acute renal failure patients group (n=64) and chronic renal fail?ure group (n=74) . Other patients with non-renal failure kidney disease (NRF group, n=80) and healthy adult (control group, n=80) were also selected. Levels of PTH,β2-MG, hs-CRP , PTH+β2-MG, PTH+hs-CRP,β2-MG+hs-CRP and PTH+β2-MG+ hs-CRP were compared between these four groups to choose the optimal combination for differential diagnosis. Re?sults Hs-CRP in ARF group was significantly higher than that in control group and CRF group. Levels of PTH andβ2-MG were significantly lower in ARF group than that in CRF groups but not in control group (P < 0.01). hs-CRP andβ2-MG in the ARF group were moderately higher (68.7%) and severely higher (81.2%) while PTH was mild higher (25%) in ARF group than those in control group, On the other hand, hs-CRP andβ2-MG in the ARF group were moderately higher (56.8%) and severely higher (98.6%) while PTH was mild higher (39.2%) in ARF group than those in control group. Combina?tion of hs-CRP withβ2-MG could increase total case rate (TCR) and Youden index (YI) of ARF;while combination of PTH andβ2-MG could improve the TCR and YI of CRF. Conclusion Combined detection of PTH,β2-MG and hs-CRP is use?ful in differential diagnosis of ARF and CRF.