Multi index evaluation of myocardial injury in cardiopulmonary bypass and off -pump coronary artery bypass grafting / 重庆医学

ABSTRACT

Objective To comparison of extracorporeal circulation coronary artery bypass grafting (CABG) with off‐pump coronary artery bypass grafting (OPCABG ) the degree of myocardial injury by multi index evaluation .Methods From January 2010 to January 2014 underwent coronary artery bypass graft operation in our hospital were randomly selected for CABG and OP ‐CABG patients ,a total of 60 cases .According to the operation mode for CABG would be recorded as the control group ,OPCABG recorded as observation group ,30 patients in each group ,compared the two groups of anesthesia induced by 5 min after operation (T0 ) ,1 d after operation (T1 ) and 2 d (T2 ) of myocardial troponin I (cTnI) concentration ,creatine kinase isoenzyme (CK‐MB) ac‐tivity ,the concentration of NT‐proBNP and interleukin‐6 (IL‐6) level .And the calculation of myocardial mitochondrial injury ,sta‐tistical comparison of systolic blood pressure (SBP) ,diastolic blood pressure (DBP) and mean arterial pressure (MAP) after 24 h . Results Two groups of patients with cTnI ,CK‐MB ,NT‐proBNP on T0 moment ,any time the level of IL‐6 had no difference(P>0 .05) .In T1 ,T2 moments ,cTnI ,CK‐MB ,NT‐proBNP and IL‐6 were lower than that of the control group (P< 0 .05) .In addition , the observation group in postoperative myocardial mitochondria injury score (1 .90 ± 0 .27) ,significantly lower than the control group (2 .80 ± 0 .31) points ;The observation group ,SBP ,DBP and MAP blood pressure index were higher than the control group , the differences were all statistically significant (P< 0 .05) .Conclusion OPCABG on myocardial injury degree is less than CABG , and the OPCABG postoperative patients recover faster and with higher clinical value .