Biological mechanisms and clinical significance of isocitrate dehydrogenase 1 mutation in glioma / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 838-840, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-480112
ABSTRACT
Isocitrate dehydrogenase 1 (IDH1), a key rate-limiting enzyme in tricarboxylic acid cycle,is found within the cytoplasm and peroxisomes.In recent years, IDH1 mutation is discovered in most gliomaand its large scale metabolites, 2-hydroxyglutarate, may be involved in tumor as potential carcinogens, and isshown to be closely related to better patients' survival as well.IDH1 mutation is anticipated to be a novel genet-ic biomarker which will guide the treatments of clinical glioma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo
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