Synthesis of N-acyl chitosan derivatives and investigation of chitosan-modified docetaxel liposomes in vitro / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 519-523, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-480428
ABSTRACT
Aim:
Synthesized N-acylated chitosan(NAC) was used to anchor on the surface of plain docetaxel li-posomes( PDL) in order to to sustain drug release. Methods; NAC of low substitution degrees were prepared using hexanoic(C_6), lauric( C_(12)), and palmitic( C_(16)) anhydrides. W-palmitoyl chitosan was chosen to anchor the do-cetaxel liposomes. In vitro release profiles of conventional liposmes and the anchored liposomes was compared.Results:
Hexanoic(C_6), lauric( C_(12)), and palmitic( C_(16)) -branched chitosans were synthesized. It was found that N-acylated chitosan-anchored DXL liposomes (NDL) increase stabilities of docetaxel liposomes. 70% of docetaxel was released from PDL in 24 hours but 39% from NDLConclusion:
Liposomes anchored by the low substituted N-acylated chitosan could decrease the drug release.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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