Expression of serum IGF-1,IGFBP-3 in children with obstructive sleep apnea hyponea syndrome / 中国耳鼻咽喉头颈外科

ABSTRACT

[ABSTRACT]OBJECTIVETo analyse the levels of serum IGF-1、IGFBP-3 in children with obstructive sleep apnea hyponea syndrome (OSAHS).METHODS50 children with OSAHS and 10 healthy children were enrolled in this study. According to the respiratory disturbance index (AHI). Serum IGF-1、IGFBP-3 of children were determined and the results were analyze.RESULTSSerum level of IGF-1 had significant statistical differences between severe OSAHS group and controls (t=4.275,P0.05). Serum IGF-1 of severe OSAHS children was negatively correlated with AHI (r=-0.505,P0.05). Serum level of IGFBP-3 in OSAHS children had no significant correlation with AHI, lowest average blood oxygen saturation and SWS sleep (P>0.05).CONCLUSION Serum levels of IGF-1 in children are more easily affected by OSAHS than serum level of IGFBP-3. Growth retardation of children with OSAHS may be related to the decrease of IGF-1 concentration.