Clinical analysis of single filtration plasmapheresis using continuous renal replacement therapy machines in kidney transplantation
Kidney Research and Clinical Practice
;
: 192-199, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-48162
ABSTRACT
BACKGROUND:
Plasmapheresis has become an essential element of kidney transplantation (KT). In the present study, we report clinical outcomes of filtration plasmapheresis using continuous renal replacement therapy machines with a single filter for the first time in Korea.METHODS:
We retrospectively analyzed six patients who underwent filtration plasmapheresis for KT in our center; plasmapheresis was performed using the Plasmaflex (Baxter®) with a TPE 2000 filter set (Baxter®) in our hemodialysis unit. Five percent albumin was used as the replacement fluid, and intravenous immunoglobulin G was administered after each plasmapheresis session. The target preoperative ABO isoagglutinin titer was less than 18.RESULTS:
Filtration plasmapheresis was performed in four patients for ABO-incompatible KT, one for antibody-mediated rejection after KT, and the last one for positive T cell crossmatch. Altogether, 46 sessions of plasmapheresis were performed. ABO isoagglutinin titers successfully declined to or below the target level in all patients, and all patients successfully received KT with no significant antibody titer rebound. Acute antibody-mediated rejection and positive T cell crossmatch were well treated with filtration plasmapheresis, and no patient required fresh frozen plasma infusion for coagulopathy. There were one episode of hypotension and three of hypocalcemia. No patients experienced bleeding, infection, or allergic reaction.CONCLUSION:
Filtration plasmapheresis was effective and safe. Although our result is from a single center, our protocol appears to be promising.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Imunoglobulina G
/
Estudos Retrospectivos
/
Diálise Renal
/
Transplante de Rim
/
Plasmaferese
/
Terapia de Substituição Renal
/
Filtração
/
Hemorragia
/
Hipersensibilidade
Tipo de estudo:
Guia de Prática Clínica
/
Estudo observacional
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS