Progress of diagnosis and treatment for maturity-onset diabetes of the young / 中华实用儿科临床杂志

ABSTRACT

Maturity-onsetdiabetesoftheyoung(MODY),amonogenicformofdiabetes,hasmorethan8 well-known subtypesMODY1( hepatocyte nuclear factor - 4A,HNF4A ),MODY2( glucokinase,GCK ),MODY3 (hepatocyte nuclear factor-1A,HNFIA),MODY4(pancreatic and duodenal homeobox,PDX),MODY5(hepatocyte nuclear factor-1B,HNFIB),MODY6(neuronal differentiation 1,NEUR0DI),MODY7(carboxyl ester lipase,CEL) and MODY8( insulin,INS). The molecular pathology,clinical manifestations and treatment of MODYs are different and reviewed.