Application of 1H-MR spectroscopy in crerbral glioma / 中国神经精神疾病杂志

ABSTRACT

Objective To investigate the application of 1H-MR spectroscopy in predicting the value of each grade range and grading of glioma invasion. Methods A restrospective analysis was conducted on the preoperative biopsy or posoperative pathology confirmed glioma in 33 cases. Cerebral gliomas were graded into four categories based on the stan?dard of WHO(2007)grade I, II, III andⅣ. All patients underwent MRI and 1H-MR spectroscopy before operation. The 1H-MR spectroscopy analysis was used to analysis metabolite NAA,Cho,Cr and NAA/Cho, NAA/Cr, Cho/Cr in the tu?mor area, peritumoral region and normal area. Results 1H-MRS revealed that there were no significantly differences in Cho, Cho/Cr, NAA/Cho between the peritumoral region and tumor area of grade I glioma (P<0.025). However, there were significantly differences in Cho, Cr, NAA/Cho, Cho/Cr ratio between peritumoral region and the normal brain tissue of grade I glioma (P<0.025). There were significantly differences in NAA, NAA/Cho, NAA/Cr ratio between peritumoral re? gion and the tumor area of grade II glioma (P<0.025). There were statistically significantly differences in Cho, NAA, Cr, NAA/Cho, NAA/Cr, Cho/Cr ratio between the peritumoral region and normal brain tissue of Grade III orⅣglioma (P<0.025). The ratio of Cho/Cr and NAA/Cho were correlated with the pathological grade(F values were 403.9 and 159.46, P<0.05), and the ratio of NAA/Cr and NAA/Cho were decreased gradually whereas the ratio of Cho/Cr was gradually in?creased(F=119.91,P<0.05). Conclusion The 1H-MR spectroscopy analysis has a predictive value in evaluating the lev?el of glioma invasion and determining the grading of glioma before surgery, which is very helpful for the surgical plan and the scope of resection, thereby reducing the recurrence and prognosis of the patients after surgery.